Generalized sterile pustular eruptions occur in various dermatoses including pustular psorisis, erythema multiforme, Sneddon-Wilinson disease and others. Recetly, actue eruptions of disseminated sterile pustules have been reported. The etiology
is
not
related to a genetic predispostion to psoriasis but to drug ingestion or viral infections, thus termed toxic pustuloderma(T.P.). In this report, we present a typical case of T.P. observed in our departemt.
Our patient, an 18-year-old male, with no personal or family history of psoriasis, was given drug medication including amoxicillin for fever and chilling sensation. Pustular eruptions first appeared on his face about two days after medication and
gradually spread to the trunk and limbs. The Skin examination revealed numerous small pustules on an erythematous base. Laboratory examination revealed neutrophilic leukocytosis and an elevated sedimentation rate. Skin biopys showed subcorneal
and
spongiform neutrophilic pustules. Upon interruption of the amoxicillin, the pustules cleared rapidly in 3 days and there has been no recurrence of any rash over a 7-month follow-up period. (Kor J Dermatol 1994 ; 32(5) : 944~949)
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